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Nevertheless, as more voltage-gated K channels become inactivated, the membrane potential recovers to its normal resting steady state..

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Thus, the fundamental difference between a neuron and a nonneuronal cell is a matter of degree.

The Hodgkin–Huxley model of an action potential in the squid giant axon has been the basis for much of the current understanding of the ionic bases of action potentials.

These allow Ca2 ions to diffuse through these channels and bind with synaptic vesicles within the terminal boutons.

Once bounded with Ca2 , the vesicles dock and fuse with the presynaptic membrane, and release neurotransmitters into the synaptic cleft by a process known as exocytosis.

Briefly, the model states that the generation of an action potential is determined by two ions: Na and K .

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